Luke played for the Mohawks in 2010 and 2011 under Coach Keith Griffin while attending the University of Kentucky. He was an 8th round draft pick of the Tampa Bay Rays in the 2012 draft. He was an All-PGCBL performer in 2011 after hitting a then league record 8 home runs on the season. He did that while only playing for the Mohawks from July 4 on. As the cleanup hitter at UK, Luke was named All-SEC catcher after hitting 16 home runs his junior season. He was the first player in the Rays 2012 draft class to reach the Major Leagues. In 2017 the Toronto Blue Jays claimed Maile off waivers from the Rays and he played 3 seasons with the Blue Jays. In 2020, Luke signed with the Pittsburgh Pirates, in 2021 he signed with the Milwaukee Brewers, in 2022 he signed with the Cleveland Guardians and made his first postseason appearence as the Guardians won the AL Central and in 2023 Luke signed with the Cincinnati Reds. In 2025, Luke signed a minor league deal with the Kansas City Royals.

Left-handed pitcher Tim Herrin from Indiana University played for the Mohawks championship team in 2016. He was drafted in the 29th Round by Cleveland in 2018 and made the Guardians Opening Day roster in 2023. He made history in his Major League debut on April 2, 2023 as he was the 1st pitcher since 1893 (when the mound was moved to its current distance) to face 4+ batters in his MLB debut and strike them all out as he set down all 4 Mariners batters he faced.

Matt Gorski played in for the Mohawks in 2017 from Indiana University. The Pittsburgh Pirates drafted him in the 2nd Round of the 2019 MLB Draft. On April 24, 2025 Gorski made his MLB debut for the Pirates and he homered in his first at-bat.

Joe LaSorsa pitched for the Mohawks in 2017 from St. John's University. He was selected in the 18th round of the 2019 MLB Draft by the Tampa Bay Rays. LaSorsa made a name for himself in the 2023 World Baseball Classic as he struck out established MLB hitters in big situations for Team Italy and would roar off the mound in celebration. On May 29, 2023, LaSorsa made his Major League debut with the Tampa Bay Rays in Wrigley Field against the Chicago Cubs. He pitched in one more game for the Rays before being claimed off waivers by the Washington Nationals, where he pitched the remainder of the 2023 season. In 2025, Joe signed with the Cincinnati Reds.

A local player, Matt Gage graudated from Broadalbin-Perth in 2011 and joined the Mohawks for their post-season run that year. In 2012, Gage returned to the Mohawks following his freshman season at Siena. The Giants selected Gage in the 10th round of the 2014 MLB Draft and he made it up to Triple-A before being released in 2018. Gage then bounced around between the Mets, the Rockies, the Mexican League and Indy ball before signing with the Blue Jays for the 2022 season. On June 6, 2022, Gage made his Major League debut with the Blue Jays. In 2023, Gage signed with the Houston Astros and split time between the Majors and Triple-A. The New York Yankees picked Gage up off waivers in 2024 and traded him to the Los Angles Dodgers. Gage pitched for the Dodgers and New York Mets jumping between the majors and minors. The Detroit Tigers signed Gage in 2025.

Andrew Saalfrank came to the Mohawks in 2017 from Indiana University. He went 7-0 in 9 starts with a 3.78 ERA and 52 strikeouts in 47.2 innings pitched. The Diamondbacks selected him in the 6th round of the 2019 MLB Draft. The 2023 season was Saalfrank's breakout year as he started the season in Double-A and finished it in the World Series with the Diamondbacks. After a stellar season in Double-A and Triple-A, the Diamondbacks called him up to make his Major League debut on September 5th against the Colorado Rockies. He made 10 appearences to close out the season and did not allow a run. He then joined the Diamondbacks for their 2023 post-season run and pitched in 11 games, including 3 appearences in the 2023 World Series.

John Nogowski (Florida State) played for the Mohawks in 2013. He hit .365, was named the PGCBL Player of the Year and lead the Mohawks to a PGCBL title. He was drafted in the 34th round by the Oakland A's in 2014 and made his Major League debut with the St. Louis Cardinals in 2020. He had a memorable 2021 season with the Pittsburgh Pirates. Following the 2021 season John signed with the San Francisco Giants but was selected in the minor league portion of the Rule 5 Draft by the Atlanta Braves in December.

Cord played for the Mohawks in 2006 while attending Stanford University. The California native had breakout years for the Cardinals in 2007 and 2008, leading them to the College World Series and hitting .355 with 16 home runs in his junior year. He was drafted in the 3rd round of the 2008 draft by the Indians and made his way quickly to the Major Leagues after tearing up AA, AAA and the Arizona Fall Leagues.

Brendan, a utility infielder, attended William and Mary College and was drafted in the 5th round of the 2001 draft by the Chicago Cubs. He played for the Mohawks in 1999 for Dennis Healy. He was a career .300 hitter in the minor leagues and in June of 2004 made his major league debut with the Chicago Cubs. He was later traded to the Montreal Expos as part of the Nomar Garciaparra trade and was a member of the Cincinnati Reds in 2006. Harris broke through in 2007 and was the everyday shortstop for the Tampa Bay Devil Rays where he had a breakout year. After spending a few years as a starter for the Minnesota Twins, he was traded to the Baltimore Orioles for the 2011 season. He is now a scout in the Los Angeles Angels organization.

Glen played for the Mohawks in 1991 for Brian Spagnola. A four year starter at The College of Saint Rose, Glen was drafted by the Detroit Tigers in the 11th round of the 1993 draft. He played minor league baseball for six seasons until he made the Houston Astros major league roster in 1999. He remained with the Astros until 2002 and played in 235 games in three seasons. Glen participated as a member of the Astros playoff roster in 1999, 2000, and 2001. After spending years as director of pacific rim scouting for Houston Astros, he was named the San 0Diego Padres minor league coordinator of outfield and baserunning.